What is the purpose of BNP and NT-proBNP in clinical practice?

The purpose of BNP (B-type Natriuretic Peptide) and NT-proBNP (N-terminal pro B-type Natriuretic Peptide) in clinical practice primarily revolves around their use as biomarkers for diagnosing heart failure. These peptides are released from the heart in response to ventricular volume expansion and pressure overload, which are common in patients suffering from heart failure. When a patient presents with symptoms such as shortness of breath or edema, measuring the levels of BNP or NT-proBNP can help clinicians confirm or rule out heart failure as the underlying cause of these symptoms.

High levels of BNP or NT-proBNP in the blood are indicative of heart stress and dysfunction, making them valuable tools for assessing the presence and severity of heart failure. Their role extends beyond just diagnosis; they can also aid in monitoring the response to treatment and the prognosis of patients with known heart failure.